Anti-Dog IL6 Polyclonal Antibody (CY328014)

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100ug

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Datasheet

Overview

Catalog No.

CY328014

Description

Anti-Dog IL6 Polyclonal Antibody (CY328014) is a rabbit polyclonal antibody detecting IL6 in ELISA, IHC, WB. Suitable for Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Dog

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Dog IL6 (Phe21-Met207).

Target

Interleukin-6, IL-6, IL6

Purification

Purified by antigen affinity column.

Accession

P41323

RRID

Anti-Dog IL6 Polyclonal Antibody (abinScience Cat# CY328014, RRID:AB_3724988)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-6 (IL6) is a ~22 kDa protein. Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. IL6 is the therapeutic target of tocilizumab (Actemra).

Note

For research use only.

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