Anti-Human Phospho-Tau (pS202/pT205) Recombinant Antibody (AT8) (HY086123)

Name: Anti-Human Phospho-Tau (pS202/pT205) Recombinant Antibody (AT8)
Brand: abinScience
SKU: HY086123
Price: 126 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY086123

Description

Anti-Human Phospho-Tau (pS202/pT205) Recombinant Antibody (AT8) (HY086123) is a mouse monoclonal antibody detecting Phospho-Tau in ELISA, SPR, IF, IHC. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, SPR, IF, IHC

Host species

Mouse

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

AT8

Target

MAPT, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau, TAU

Endotoxin level

< 10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P10636

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Microtubule-associated protein tau (P-Tau) is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76. PMID: 21985311

2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079. PMID: 32961270

Note

For research use only.

Images

Bioactivity

SEC-HPLC detection for Anti-Human Phospho-Tau (pS202/pT205) Antibody (AT8).
SDS-PAGE

SDS-PAGE for Anti-Human Phospho-Tau (pS202/pT205) Antibody (AT8).