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InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0196) (VK623020)

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InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0196)

InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0196)

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Spec:

100ug
1mg

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Datasheet

Overview

Catalog No.	VK623020
Description	InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0196) [Iv0196] (VK623020) is a human monoclonal antibody detecting Envelope glycoprotein in ELISA, Neutralization. Suitable for Zaire ebolavirus.
Species reactivity	Zaire ebolavirus
Applications	ELISA, Neutralization
Host species	Human
Isotype	IgG1, kappa
Clone ID	Iv0196
Clonality	Monoclonal
Target	Envelope glycoprotein, GP1, 2, GP, Shed GP, GP1, 2-delta, GP1, GP2, GP
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q05320
RRID	InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0196) (abinScience Cat# VK623020, RRID:AB_3727231)
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity) (Probable). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes. 1. Simmons, G. et al. (2002) Journal of virology 76, 2518-28. PMID: 11836430 2. Takada, A. et al. (2000) Virology 278, 20-6. PMID: 11112476 3. Iampietro, M. et al. (2017) PLoS pathogens 13, e1006397. PMID: 28542576 4. Edri, A. et al. (2018) Frontiers in immunology 9, 1428. PMID: 30013549 5. Vande Burgt, NH. et al. (2015) Viruses 7, 5587-602. PMID: 26516900 6. Brinkmann, C. et al. (2016) Journal of virology 90, 11075-11086. PMID: 27707924 7. González-Hernández, M. et al. (2018) Journal of virology 92. PMID: 29669839 8. Rizk, MG. et al. (2017) Journal of virology 91. PMID: 28878074
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0196).

References

Datasheet

InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0196).pdf

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InVivoMAb Anti-ZEBOV GP/Envelope glycoprotein Antibody (Iv0196)