Anti-Human BIN1 Recombinant Antibody (SAA1499) (HT430013)

Name: Anti-Human BIN1 Recombinant Antibody (SAA1499)
Brand: abinScience
SKU: HT430013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT430013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1499

Clonality

Monoclonal

Target

AMPHL, Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O00499

RRID

Anti-Human BIN1 Antibody (SAA1499) (abinScience Cat# HT430013, RRID:AB_3727260)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Myc box-dependent-interacting protein 1 (BIN1/Amphiphysin-II) is a ~64 kDa protein. Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates.

1. Wu, T. et al. (2014) PloS one 9, e93060. PMID: 24755653

2. Miyagawa, T. et al. (2016) Human molecular genetics 25, 2948-2958. PMID: 27179792

3. Sakamuro, D. et al. (1996) Nature genetics 14, 69-77. PMID: 8782822

4. Dräger, NM. et al. (2017) EMBO reports 18, 2051-2066. PMID: 28893863

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human BIN1 Antibody (SAA1499)

References

Datasheet

Anti-Human BIN1 Recombinant Antibody (SAA1499).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human BIN1 Recombinant Antibody (SAA1499) (HT430013)

Overview

Images

References

Datasheet

SDS

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