Anti-Human C7 Recombinant Antibody (SAA1569) (HY181013)

Name: Anti-Human C7 Recombinant Antibody (SAA1569)
Brand: abinScience
SKU: HY181013
Price: 196 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY181013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1569

Clonality

Monoclonal

Target

C7, Complement component C7

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P10643

RRID

Anti-Human C7 Antibody (SAA1569) (abinScience Cat# HY181013, RRID:AB_3727330)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Complement component C7 (Complement C7) is a ~93 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending.

1. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194

2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837

3. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168

4. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328

5. DiScipio, RG. et al. (1988) The Journal of biological chemistry 263, 549-60. PMID: 3335508

6. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456

7. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human C7 Antibody (SAA1569)

References

Datasheet

Anti-Human C7 Recombinant Antibody (SAA1569).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human C7 Recombinant Antibody (SAA1569) (HY181013)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us