Anti-Human TSPAN8 Recombinant Antibody (SAA1592) (HB737013)

Name: Anti-Human TSPAN8 Recombinant Antibody (SAA1592)
Brand: abinScience
SKU: HB737013
Price: 196 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB737013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1592

Clonality

Monoclonal

Target

TSPAN8, Tspan-8, Tumor-associated antigen CO-029, TM4SF3, Transmembrane 4 superfamily member 3, Tetraspanin-8

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P19075

RRID

Anti-Human TSPAN8 Antibody (SAA1592) (abinScience Cat# HB737013, RRID:AB_3727353)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Tetraspanin-8 (TSPAN8) is a ~26 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR.

1. Schmidt, F. et al. (2016) Biological chemistry. PMID: 27180357

2. Müller, M. et al. (2022) Cells 11. PMID: 36078095

3. Pan, SJ. et al. (2015) International journal of molecular sciences 16, 5363-74. PMID: 25761241

4. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232

5. Min, J. et al. (2023) Cellular and molecular life sciences : CMLS 80, 154. PMID: 37204469

6. Zhu, Y. et al. (2023) Cancers 15. PMID: 37835445

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human TSPAN8 Antibody (SAA1592)

References

Datasheet

Anti-Human TSPAN8 Recombinant Antibody (SAA1592).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human TSPAN8 Recombinant Antibody (SAA1592) (HB737013)

Overview

Images

References

Datasheet

SDS

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