Anti-Human CLDN2 Antibody (SAA1651) (HX983013)

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50ug
100ug
1mg

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Overview
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Datasheet

Overview

Catalog No.

HX983013

Description

Anti-Human CLDN2 Antibody (SAA1651) [SAA1651] (HX983013) is a mouse monoclonal antibody detecting CLDN2 in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1651

Clonality

Monoclonal

Target

CLDN2, SP82, Claudin-2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P57739

RRID

Anti-Human CLDN2 Antibody (SAA1651) (abinScience Cat# HX983013, RRID:AB_3727412)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Claudin-2 (CLDN2) is a ~24 kDa protein. Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response. In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream. In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients.

1. Rosenthal, R. et al. (2010) Journal of cell science 123, 1913-21. PMID: 20460438

2. Gonschior, H. et al. (2022) Nature communications 13, 4985. PMID: 36008380

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CLDN2 Antibody (SAA1651)

References

Datasheet

Anti-Human CLDN2 Antibody (SAA1651).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CLDN2 Antibody (SAA1651) (HX983013)

Overview

Images

References

Datasheet

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