Anti-Human NPR1/NPR-A Antibody (SAA1818) (HB010013)

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Datasheet

Overview

Catalog No.

HB010013

Description

Anti-Human NPR1/NPR-A Antibody (SAA1818) [SAA1818] (HB010013) is a human monoclonal antibody detecting NPR-A in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Human

Isotype

IgG4, kappa

Clone ID

SAA1818

Clonality

Monoclonal

Target

ANP-A, Atrial natriuretic peptide receptor type A, Guanylate cyclase A, NPR1, NPR-A, ANPRA, GC-A, ANPR-A, Atrial natriuretic peptide receptor 1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16066

RRID

Anti-Human NPR1/NPR-A Antibody (SAA1818) (abinScience Cat# HB010013, RRID:AB_3727580)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Atrial natriuretic peptide receptor 1 (NPR1/NPR-A) is a ~118 kDa protein. Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis.

1. Liu, S. et al. (2025) Nature structural & molecular biology 32, 469-478. PMID: 39543315

2. Long, C. et al. (2022) Aging cell 21, e13699. PMID: 36016499

Note

For research use only.

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