Anti-Human SCN9A Recombinant Antibody (SAA1834) (HS929013)

Name: Anti-Human SCN9A Recombinant Antibody (SAA1834)
Brand: abinScience
SKU: HS929013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HS929013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1834

Clonality

Monoclonal

Target

Sodium channel protein type 9 subunit alpha, NENA, Neuroendocrine sodium channel, Sodium channel protein type IX subunit alpha, SCN9A, Voltage-gated sodium channel subunit alpha Nav1.7, PN1, Peripheral sodium channel 1, hNE-Na

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15858

RRID

Anti-Human SCN9A Antibody (SAA1834) (abinScience Cat# HS929013, RRID:AB_3727597)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Sodium channel protein type 9 subunit alpha (SCN9A/Nav1.7) is a ~226 kDa protein. Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain.

1. Cummins, TR. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8232-6. PMID: 15385606

2. Choi, JS. et al. (2006) Neurology 67, 1563-7. PMID: 16988069

3. Fertleman, CR. et al. (2006) Neuron 52, 767-74. PMID: 17145499

4. Cox, JJ. et al. (2006) Nature 444, 894-8. PMID: 17167479

5. Han, C. et al. (2009) Brain : a journal of neurology 132, 1711-22. PMID: 19369487

6. Eberhardt, M. et al. (2014) The Journal of biological chemistry 289, 1971-80. PMID: 24311784

7. Tan, ZY. et al. (2014) FEBS letters 588, 3964-9. PMID: 25240195

8. Ahuja, S. et al. (2015) Science (New York, N.Y.) 350, aac5464. PMID: 26680203

9. Klugbauer, N. et al. (1995) The EMBO journal 14, 1084-90. PMID: 7720699

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human SCN9A Antibody (SAA1834)

References

Datasheet

Anti-Human SCN9A Recombinant Antibody (SAA1834).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SCN9A Recombinant Antibody (SAA1834) (HS929013)

Overview

Images

References

Datasheet

SDS

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