Anti-Human TSHR/LGR3 Recombinant Antibody (CS-17) (HB852033)

Name: Anti-Human TSHR/LGR3 Recombinant Antibody (CS-17)
Brand: abinScience
SKU: HB852033
Price: 126 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB852033

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

CS-17

Clonality

Monoclonal

Target

Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16473

RRID

Anti-Human TSHR/LGR3 Antibody (CS-17) (abinScience Cat# HB852033, RRID:AB_3729295)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Thyrotropin receptor (TSHR/LGR3) is a ~86 kDa protein. Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS).

1. Costagliola, S. et al. (2002) The EMBO journal 21, 504-13. PMID: 11847099

2. Nakabayashi, K. et al. (2002) The Journal of clinical investigation 109, 1445-52. PMID: 12045258

3. Faust, B. et al. (2022) Nature 609, 846-853. PMID: 35940205

4. Duan, J. et al. (2022) Nature 609, 854-859. PMID: 35940204

5. Morgan, SJ. et al. (2016) Thyroid : official journal of the American Thyroid Association 26, 1794-1803. PMID: 27638195

Note

For research use only.

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