Anti-Human TREM2 Antibody (SAA2089) (HV166043)

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Datasheet

Overview

Catalog No.

HV166043

Description

Anti-Human TREM2 Antibody (SAA2089) [SAA2089] (HV166043) is a human monoclonal antibody detecting TREM2 in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Human

Isotype

VHH-hFc

Clone ID

SAA2089

Clonality

Monoclonal

Target

Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2, TREM2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NZC2

RRID

Anti-Human TREM2 Antibody (SAA2089) (abinScience Cat# HV166043, RRID:AB_3729349)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~25 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin.

1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849

2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018

3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356

4. Sudom, A. et al. (2018) The Journal of biological chemistry 293, 12634-12646. PMID: 29794134

5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881

6. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066

7. Bouchon, A. et al. (2001) The Journal of experimental medicine 194, 1111-22. PMID: 11602640

8. Paloneva, J. et al. (2003) The Journal of experimental medicine 198, 669-75. PMID: 12925681

Note

For research use only.

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