Anti-Human CD274/PD-L1/B7-H1 Recombinant Antibody (405.9A11) (HV974093)

Name: Anti-Human CD274/PD-L1/B7-H1 Recombinant Antibody (405.9A11)
Brand: abinScience
SKU: HV974093
Price: 126 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV974093

Species reactivity

Human

Applications

IHC, WB

Host species

Mouse

Isotype

IgG1

Clone ID

405.9A11

Clonality

Monoclonal

Target

B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, CD19, CD19

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P15391

RRID

Anti-Human CD274/PD-L1/B7-H1 Antibody (405.9A11) (abinScience Cat# HV974093, RRID:AB_3729397)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

B-lymphocyte antigen CD19 (CD274/PD-L1) is a ~61 kDa protein. Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. CD274 is the therapeutic target of atezolizumab (Tecentriq) and durvalumab (Imfinzi).

1. Vanshylla, K. et al. (2018) Scientific reports 8, 4244. PMID: 29523808

2. Carter, RH. et al. (1992) Science (New York, N.Y.) 256, 105-7. PMID: 1373518

3. van Zelm, MC. et al. (2006) The New England journal of medicine 354, 1901-12. PMID: 16672701

4. de Rie, MA. et al. (1989) Cellular immunology 118, 368-81. PMID: 2463100

5. Wang, Y. et al. (2002) Immunity 17, 501-14. PMID: 12387743

6. Sato, S. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 3278-87. PMID: 9317126

7. Buhl, AM. et al. (1997) The Journal of experimental medicine 186, 1897-910. PMID: 9382888

Note

For research use only.

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