Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194) (HP392013)

Name: Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194)
Brand: abinScience
SKU: HP392013
Price: 191 USD
Availability: InStock

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1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HP392013

Species reactivity

Human

Applications

ELISA, IF, IP

Host species

Mouse

Isotype

IgG2a

Clone ID

SAA0194

Clonality

Monoclonal

Target

ROX, MAPJD, C14orf169, hsNO66, Myc-associated protein with JmjC domain, Ribosomal oxygenase 1, Nucleolar protein 66, Ribosomal oxygenase NO66, Histone lysine demethylase NO66, 60S ribosomal protein L8 histidine hydroxylase, NO66, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, RIOX1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9H6W3

RRID

Anti-Human RIOX1/C14ORF169 IP Antibody (SAA0194) (abinScience Cat# HP392013, RRID:AB_3729728)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Ribosomal oxygenase 1 (RIOX1/C14ORF169) is a ~71 kDa protein. Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation.

1. Ge, W. et al. (2012) Nature chemical biology 8, 960-962. PMID: 23103944

2. Suzuki, C. et al. (2007) Molecular cancer therapeutics 6, 542-51. PMID: 17308053

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human RIOX1/C14ORF169 IP Antibody (SAA0194)

References

Datasheet

Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194) (HP392013)

Overview

Images

References

Datasheet

SDS

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