Anti-influenza A virus (H5N1) Non-structural protein 1 Recombinant Antibody (2H6) (VK013013)

Name: Anti-influenza A virus (H5N1) Non-structural protein 1 Recombinant Antibody (2H6)
Brand: abinScience
SKU: VK013013
Price: 191 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

VK013013

Species reactivity

Influenza A virus (H5N1), Influenza A virus (H1N1)

Applications

WB, ELISA

Host species

Mouse

Isotype

IgG1

Clone ID

2H6

Clonality

Monoclonal

Target

NS1

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O56264

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Non-structural protein 1 (NS1) is a ~26 kDa protein. Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism. Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated RIGI ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7.

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-influenza A virus (H5N1) Non-structural protein 1 Antibody (2H6)

References

Datasheet

Anti-influenza A virus (H5N1) Non-structural protein 1 Recombinant Antibody (2H6).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-influenza A virus (H5N1) Non-structural protein 1 Recombinant Antibody (2H6) (VK013013)

Overview

Images

References

Datasheet

SDS

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