Anti-Human GBP2 Polyclonal Antibody (HW478014)

Name: Anti-Human GBP2 Polyclonal Antibody
Brand: abinScience
SKU: HW478014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HW478014

Description

Anti-Human GBP2 Polyclonal Antibody (HW478014) is a rabbit polyclonal antibody detecting GBP2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GBP2 (Thr35-Asn276).

Target

Guanylate-binding protein 2, EC:3.6.5.-, GTP-binding protein 2, GBP-2, HuGBP-2, Guanine nucleotide-binding protein 2, Interferon-induced guanylate-binding protein 2, GBP2

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P32456

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
WB	1:500-1:2000
IHC	1:50-1:500

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Guanylate-binding protein 2 (GBP2) is a ~67 kDa protein. Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome.

1. Braun, E. et al. (2019) Cell reports 27, 2092-2104.e10. PMID: 31091448

2. Neun, R. et al. (1996) FEBS letters 390, 69-72. PMID: 8706832

Note

For research use only

Images

References

Datasheet

Anti-Human GBP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human GBP2 Polyclonal Antibody (HW478014)

Overview

Images

References

Datasheet

SDS

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