Anti-Human CD21/CR2 Polyclonal Antibody (HB939014)

Name: Anti-Human CD21/CR2 Polyclonal Antibody
Brand: abinScience
SKU: HB939014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HB939014

Description

Anti-Human CD21/CR2 Polyclonal Antibody (HB939014) is a rabbit polyclonal antibody detecting CD21 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD21/CR2 (Lys729-Asp958).

Target

Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21, CR2, C3DR

Endotoxin level

Please contact with the lab for this information.

Observed Molecular Weight

~140 kDa

Purification

Purified by antigen affinity column.

Accession

P20023

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Complement receptor type 2 (CD21/CR2) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner.

1. Delcayre, AX. et al. (1991) The EMBO journal 10, 919-26. PMID: 1849076

2. van den Elsen, JM. et al. (2011) Science (New York, N.Y.) 332, 608-11. PMID: 21527715

3. Barel, M. et al. (1995) Molecular immunology 32, 389-97. PMID: 7753047

4. Bradbury, LE. et al. (1992) Journal of immunology (Baltimore, Md. : 1950) 149, 2841-50. PMID: 1383329

5. Franco, A. et al. (2018) International immunology 30, 569-578. PMID: 30107486

6. Barel, M. et al. (2003) European journal of immunology 33, 2557-66. PMID: 12938232

7. Aubry, JP. et al. (1992) Nature 358, 505-7. PMID: 1386409

Note

For research use only

Images

References

Datasheet

Anti-Human CD21/CR2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human CD21/CR2 Polyclonal Antibody (HB939014)

Overview

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References

Datasheet

SDS

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