Anti-NFATC4 Polyclonal Antibody (HA801014)

Name: Anti-NFATC4 Polyclonal Antibody
Brand: abinScience
SKU: HA801014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HA801014

Description

Anti-NFATC4 Polyclonal Antibody (HA801014) is a rabbit polyclonal antibody detecting cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3; NFATC4; NFAT3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant human NFATC4 (Pro396-Pro685).

Target

Nuclear factor of activated T-cells, cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3; NFATC4; NFAT3

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q14934, Q8K120, D3Z9H7

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4) is a ~95 kDa protein. Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4. Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function.

1. Yang, T. et al. (2001) The Journal of biological chemistry 276, 39569-76. PMID: 11514544

2. Yang, TT. et al. (2002) Molecular and cellular biology 22, 3892-904. PMID: 11997522

3. Cho, YY. et al. (2007) The Journal of biological chemistry 282, 8380-92. PMID: 17213202

4. Yao, K. et al. (2007) Cancer research 67, 8725-35. PMID: 17875713

5. Qin, X. et al. (2008) Cellular and molecular life sciences : CMLS 65, 2752-62. PMID: 18668201

6. Mei, Z. et al. (2015) Neurochemical research 40, 829-36. PMID: 25663301

7. Hoey, T. et al. (1995) Immunity 2, 461-72. PMID: 7749981

8. Yang, TT. et al. (2008) Molecular and cellular biology 28, 3489-501. PMID: 18347059

Note

For research use only

Images

References

Datasheet

Anti-NFATC4 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-NFATC4 Polyclonal Antibody (HA801014)

Overview

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References

Datasheet

SDS

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