Anti-Human SLC13A3 Polyclonal Antibody (HB405014)

Name: Anti-Human SLC13A3 Polyclonal Antibody
Brand: abinScience
SKU: HB405014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HB405014

Description

Anti-Human SLC13A3 Polyclonal Antibody (HB405014) is a rabbit polyclonal antibody detecting Na(+)/dicarboxylate cotransporter 3; NaDC-3; hNaDC3; Na(+)-coupled carboxylate transporter 3; NaC3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3; SLC13A3; SLC13A3; NADC3; SDCT2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human SLC13A3 (Ile158-Ile230).

Target

Na(+)/dicarboxylate cotransporter 3; NaDC-3; hNaDC3; Na(+)-coupled carboxylate transporter 3; NaC3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3; SLC13A3; SLC13A3; NADC3; SDCT2

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q8WWT9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Na(+)/dicarboxylate cotransporter 3 (SLC13A3) is a ~66 kDa protein. High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood. Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response.

1. Wang, H. et al. (2000) American journal of physiology. Cell physiology 278, C1019-30. PMID: 10794676

2. Huang, W. et al. (2000) The Journal of pharmacology and experimental therapeutics 295, 392-403. PMID: 10992006

3. Burckhardt, BC. et al. (2005) American journal of physiology. Renal physiology 288, F792-9. PMID: 15561973

4. Stellmer, F. et al. (2007) Journal of molecular medicine (Berlin, Germany) 85, 763-70. PMID: 17356845

5. Bai, XY. et al. (2007) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 2409-17. PMID: 17426067

6. Schorbach, L. et al. (2013) Nephron. Physiology 124, 1-5. PMID: 24247155

7. Dewulf, JP. et al. (2019) Annals of neurology 85, 385-395. PMID: 30635937

8. Li, Y. et al. (2025) Nature structural & molecular biology 32, 502-512. PMID: 39622972

9. Chen, C. et al. (2024) Developmental cell 59, 2807-2817.e8. PMID: 39116875

Note

For research use only

Images

References

Datasheet

Anti-Human SLC13A3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human SLC13A3 Polyclonal Antibody (HB405014)

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Datasheet

SDS

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