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Anti-PHLPP2 Polyclonal Antibody (HB456014)

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Overview
Catalog No.HB456014
Description
Anti-PHLPP2 Polyclonal Antibody (HB456014) is a rabbit polyclonal antibody detecting PH domain leucine-rich repeat-containing protein phosphatase 2; 3.1.3.16; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like; PHLPP2; KIAA0931; PHLPPL in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant human PHLPP2 (Leu97-Val247).
Target PH domain leucine-rich repeat-containing protein phosphatase 2; 3.1.3.16; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like; PHLPP2; KIAA0931; PHLPPL
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q6ZVD8, Q8BXA7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2) is a ~146 kDa protein. Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3.

1. Qiao, M. et al. (2010) Molecular cell 38, 512-23. PMID: 20513427
2. Liu, J. et al. (2011) Molecular and cellular biology 31, 4917-27. PMID: 21986499
3. Li, X. et al. (2014) Gastroenterology 146, 1301-12.e1-10. PMID: 24530606
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-PHLPP2 Polyclonal Antibody

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