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Anti-PHF2 Polyclonal Antibody (HB551014)

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Overview
Catalog No.HB551014
Description
Anti-PHF2 Polyclonal Antibody (HB551014) is a rabbit polyclonal antibody detecting Lysine-specific demethylase PHF2; 1.14.11.-; GRC5; PHD finger protein 2; PHF2; CENP-35; KIAA0662 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant human PHF2 (Gln83-Arg450).
Target Lysine-specific demethylase PHF2; 1.14.11.-; GRC5; PHD finger protein 2; PHF2; CENP-35; KIAA0662
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O75151, Q9WTU0
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Lysine-specific demethylase PHF2 is a ~120 kDa protein. Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.

1. Wen, H. et al. (2010) The Journal of biological chemistry 285, 9322-9326. PMID: 20129925
2. Horton, JR. et al. (2011) Journal of molecular biology 406, 1-8. PMID: 21167174
3. Baba, A. et al. (2011) Nature cell biology 13, 668-75. PMID: 21532585
Note For research use only
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Datasheet
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Formula
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V₁ (Stock Vol.)
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Anti-PHF2 Polyclonal Antibody

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