Anti-IGFBP5 Polyclonal Antibody (HC001014)

Name: Anti-IGFBP5 Polyclonal Antibody
Brand: abinScience
SKU: HC001014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HC001014

Description

Anti-IGFBP5 Polyclonal Antibody (HC001014) is a rabbit polyclonal antibody detecting Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5; IGFBP5; IBP5 in ELISA, IHC, WB. Suitable for Human, Pig, Bovine, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human IGFBP5 (Cys30-Glu121).

Target

Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5; IGFBP5; IBP5

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P24593, Q28985, Q05717, Q07079, P24594

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Insulin-like growth factor-binding protein 5 (IGFBP5) is a ~30 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells. Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling. Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs.

1. Busby, WH. et al. (2009) Osteoarthritis and cartilage 17, 547-55. PMID: 18930415

2. Jones, JI. et al. (1993) The Journal of cell biology 121, 679-87. PMID: 7683690

3. Yamaguchi, Y. et al. (2011) Journal of cellular and molecular medicine 15, 957-69. PMID: 20345844

4. Su, Y. et al. (2015) PloS one 10, e0130546. PMID: 26103640

5. Lin, W. et al. (2023) Nature communications 14, 1578. PMID: 36949068

Note

For research use only

Images

References

Datasheet

Anti-IGFBP5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-IGFBP5 Polyclonal Antibody (HC001014)

Overview

Images

References

Datasheet

SDS

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