Anti-XPO4 Polyclonal Antibody (HC006014)

Name: Anti-XPO4 Polyclonal Antibody
Brand: abinScience
SKU: HC006014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HC006014

Description

Anti-XPO4 Polyclonal Antibody (HC006014) is a rabbit polyclonal antibody in ELISA, IHC, WB. Suitable for Human, Chicken, Mouse, Frog, and Zebrafish.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human XPO4 (Met28-Asn256).

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q9C0E2, Q5ZMR9, Q9ESJ0, Q499Y0, Q802D3

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Exportin-4 (XPO4) is a ~130 kDa protein. Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport.

1. Lipowsky, G. et al. (2000) The EMBO journal 19, 4362-71. PMID: 10944119

2. Kurisaki, A. et al. (2006) Molecular and cellular biology 26, 1318-32. PMID: 16449645

3. Bhardwaj, A. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E538-47. PMID: 26787900

Note

For research use only

Images

References

Datasheet

Anti-XPO4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-XPO4 Polyclonal Antibody (HC006014)

Overview

Images

References

Datasheet

SDS

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