Anti-Human VHL Monoclonal Antibody (1A521) (HW527015)

Name: Anti-Human VHL Monoclonal Antibody (1A521)
Brand: abinScience
SKU: HW527015
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HW527015
Description	Anti-Human VHL Monoclonal Antibody (1A521) [1A521] (HW527015) is a mouse monoclonal antibody detecting VHL in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Isotype	IgG
Clone ID	1A521
Clonality	Monoclonal
Immunogen	E. coli - derived recombinant human VHL (Glu70-Asp213).
Target	von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
Purification	Protein A/G purified from cell culture supernatant.
Accession	P40337
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	von Hippel-Lindau disease tumor suppressor (VHL) is a ~24 kDa protein. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR. 1. Tanimoto, K. et al. (2000) The EMBO journal 19, 4298-309. PMID: 10944113 2. Cheng, J. et al. (2007) Cell 131, 584-95. PMID: 17981124 3. Xie, L. et al. (2009) Science signaling 2, ra33. PMID: 19584355 4. Ganner, A. et al. (2021) Scientific reports 11, 14827. PMID: 34290272
Note	For research use only.