Anti-Human CD35 Monoclonal Antibody (1A627) (HB625015)

Name: Anti-Human CD35 Monoclonal Antibody (1A627)
Brand: abinScience
SKU: HB625015
Price: 106 USD
Availability: InStock

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Catalog No.	HB625015
Description	Anti-Human CD35/CR1 Monoclonal Antibody (1A627) [1A627] (HB625015) is a mouse monoclonal antibody detecting CD35 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Isotype	IgG
Clone ID	1A627
Clonality	Monoclonal
Immunogen	E. coli - derived recombinant human CD35/CR1 (Asp1740-Asp1971).
Target	Complement receptor type 1, C3b/C4b receptor, CD35, CR1
Purification	Protein A/G purified from cell culture supernatant.
Accession	P17927
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Complement receptor type 1 (CD35/CR1) is a ~223 kDa protein. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. 1. Schifferli, JA. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 140, 899-904. PMID: 2963069 2. Klickstein, LB. et al. (1988) The Journal of experimental medicine 168, 1699-717. PMID: 2972794 3. Krych, M. et al. (1994) The Journal of biological chemistry 269, 13273-8. PMID: 8175757 4. Török, K. et al. (2015) Immunology letters 164, 117-24. PMID: 25742728
Note	For research use only.

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Anti-Human CD35 Monoclonal Antibody (1A627).pdf

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Anti-Human CD35 Monoclonal Antibody (1A627) (HB625015)

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