Anti-MARV GP/Envelope glycoprotein Antibody (SAA2592) (VK669053)

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50ug
100ug
1mg

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Overview
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Datasheet

Overview

Catalog No.

VK669053

Description

Anti-MARV GP/Envelope glycoprotein Antibody (SAA2592) [SAA2592] (VK669053) is a human monoclonal antibody detecting Envelope glycoprotein in ELISA, Neutralization.

Species reactivity

Marburg virus (MARV)

Applications

ELISA, Neutralization

Host species

Human

Isotype

IgG1, kappa

Clone ID

SAA2592

Clonality

Monoclonal

Target

Envelope glycoprotein, GP, GP1, GP1,2, GP2, Virion spike glycoprotein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q1PDC7

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Envelope glycoprotein (GP) is a ~75 kDa protein. GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection).

Note

For research use only

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References

Datasheet