Anti-Human TGM2 Recombinant Antibody (SAA2703) (HB247013)

Name: Anti-Human TGM2 Recombinant Antibody (SAA2703)
Brand: abinScience
SKU: HB247013
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HB247013
Species reactivity	Human
Applications	ELISA, FuncS
Host species	Human
Isotype	IgGA, kappa
Clone ID	SAA2703
Clonality	Monoclonal
Target	EC:2.3.1.-, EC:2.3.2.13, EC:3.4.-.-, EC:3.5.1.44, Erythrocyte transglutaminase, G(h), Heart G alpha(h), Isopeptidase TGM2, Protein G alpha(h), Protein-glutamine deamidase TGM2, Protein-glutamine dopaminyltransferase TGM2, Protein-glutamine gamma-glutamyltransferase 2, Protein-glutamine histaminyltransferase TGM2, Protein-glutamine noradrenalinyltransferase TGM2, Protein-glutamine serotonyltransferase TGM2, TG(C), TG2, TGC, TGM2, TGase C, TGase H, TGase II, TGase-2, Tissue transglutaminase, Transglutaminase C, Transglutaminase H, Transglutaminase II, Transglutaminase-2, hTG2, hhG alpha(h), tTG, tTgase
Endotoxin level	<10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P21980
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. 1. Kanchan, K. et al. (2013) The Biochemical journal 455, 261-72. PMID: 23941696 2. Jeong, EM. et al. (2020) International journal of molecular sciences 21. PMID: 31991788 3. Nemes, Z. et al. (1997) The Journal of biological chemistry 272, 20577-83. PMID: 9252372 4. Upchurch, HF. et al. (1991) Journal of cellular physiology 149, 375-82. PMID: 1683874 5. Lai, TS. et al. (2017) Amino acids 49, 501-515. PMID: 27270573 6. Hernandez-Fernaud, JR. et al. (2017) Nature communications 8, 14206. PMID: 28198360 7. Melino, G. et al. (1994) Molecular and cellular biology 14, 6584-96. PMID: 7935379 8. Hsieh, YF. et al. (2013) PloS one 8, e81516. PMID: 24349085
Note	For research use only