Anti-CXCR4 Reference Antibody (REGN7663, RUO) (HX206086)

Name: Anti-CXCR4 Reference Antibody (REGN7663, RUO)
Brand: abinScience
SKU: HX206086
Price: 370 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HX206086

Description

Anti-CD184/CXCR4 Antibody (REGN7663) (HX206086) is a research-grade recombinant antibody targeting CD184.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

Species reactivity

Human

Applications

ELISA, FACS, Functional assay

Host species

Human

Isotype

IgG

Clone ID

REGN7663

Clonality

Monoclonal

Target

C-X-C chemokine receptor type 4, CD184, CXC-R4, CXCR-4, CXCR4, FB22, Fusin, HM89, LAP-3, LCR1, LESTR, LPS-associated protein 3, Leukocyte-derived seven transmembrane domain receptor, Lipopolysaccharide-associated protein 3, NPYRL, SDF-1 receptor, Stromal cell-derived factor 1 receptor

Endotoxin level

< 10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P61073

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

C-X-C chemokine receptor type 4 (CD184/CXCR4) is a ~39 kDa protein. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g.

1. Brelot, A. et al. (1999) Journal of virology 73, 2576-86. PMID: 10074102

2. Gupta, SK. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 2368-72. PMID: 10452968

3. Cheng, ZJ. et al. (2000) The Journal of biological chemistry 275, 2479-85. PMID: 10644702

4. Brelot, A. et al. (2000) The Journal of biological chemistry 275, 23736-44. PMID: 10825158

5. Veldkamp, CT. et al. (2008) Science signaling 1, ra4. PMID: 18799424

6. Busillo, JM. et al. (2010) The Journal of biological chemistry 285, 7805-17. PMID: 20048153

7. Malik, R. et al. (2010) Molecular biology of the cell 21, 2529-41. PMID: 20505072

8. Cao, Y. et al. (2015) Leukemia 29, 169-76. PMID: 24912431

9. Lear, T. et al. (2017) American journal of physiology. Cell physiology 313, C584-C592. PMID: 28978524

10. Bleul, CC. et al. (1996) Nature 382, 829-33. PMID: 8752280

Note

For research use only.

Images

References

Datasheet

Anti-CXCR4 Reference Antibody (REGN7663, RUO).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-CXCR4 Reference Antibody (REGN7663, RUO) (HX206086)

Overview

Images

References

Datasheet

SDS

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