Anti-RVFV Glycoprotein N/Gn Antibody (SAA2775) (VK101013)

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100ug
1mg

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Overview

Catalog No.	VK101013
Description	Anti-RVFV Glycoprotein N/Gn Antibody (SAA2775) (VK101013) is a human monoclonal antibody detecting Glycoprotein N. Suitable for RVFV.
Species reactivity	Rift valley fever virus (RVFV)
Applications	ELISA, Neutralization, in vivo
Host species	Human
Isotype	IgG1, kappa
Clone ID	SAA2775
Clonality	Monoclonal
Target	Envelopment polyprotein, GP, Glycoprotein G1, Glycoprotein N, Gn
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P21401
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Envelopment polyprotein (Gn) is a ~130 kDa protein. Structural component of the virion that interacts with glycoprotein C. It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion. The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation. They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion. Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly. 1. Freiberg, AN. et al. (2008) Journal of virology 82, 10341-8. PMID: 18715915 2. Halldorsson, S. et al. (2018) Nature communications 9, 349. PMID: 29367607 3. Lozach, PY. et al. (2011) Cell host & microbe 10, 75-88. PMID: 21767814 4. Piper, ME. et al. (2011) PloS one 6, e18070. PMID: 21445316
Note	For research use only