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Anti-Human HDAC7 Polyclonal Antibody (HV082014)

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Overview
Catalog No.HV082014
Description
Anti-Human HDAC7 Polyclonal Antibody (HV082014) is a rabbit polyclonal antibody detecting HDAC7. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human HDAC7 (Ser482-Ser903).
Target EC:3.5.1.-, EC:3.5.1.98, HD7, HD7a, HDAC7, HDAC7A, Histone deacetylase 7, Histone deacetylase 7A, Protein deacetylase HDAC7
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q8WUI4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Histone deacetylase 7 (HDAC7) is a ~102 kDa protein. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.

1. Bryant, H. et al. (2002) Journal of virology 76, 10290-8. PMID: 12239305
2. Li, B. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 4571-6. PMID: 17360565
3. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758
4. Zhang, XL. et al. (2023) Nature communications 14, 3815. PMID: 37369679
Note For research use only
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Formula
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human HDAC7 Polyclonal Antibody

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