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Anti-Human ASPN Polyclonal Antibody (HV743014)

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Overview
Catalog No.HV743014
Description
Anti-Human ASPN Polyclonal Antibody (HV743014) is a rabbit polyclonal antibody detecting ASPN. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityMouse, Human
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human ASPN (Phe57-Met371).
Target ASPN, Asporin, PLAP-1, PLAP1, Periodontal ligament-associated protein 1, SLRR1C
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9BXN1
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Asporin (ASPN) is a ~43 kDa protein. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins. Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

Note For research use only
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Formula
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human ASPN Polyclonal Antibody

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