Anti-Human IL-33 Polyclonal Antibody (HF543014)

Name: Anti-Human IL-33 Polyclonal Antibody
Brand: abinScience
SKU: HF543014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HF543014

Description

Anti-Human IL33 Polyclonal Antibody (HF543014) is a rabbit polyclonal antibody detecting IL33. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human IL33 (Ser112-Thr270).

Target

C9orf26, IL-1F11, IL-33, IL1F11, IL33, Interleukin-1 family member 11, Interleukin-33, Interleukin-33 (109-270), Interleukin-33 (95-270), Interleukin-33 (99-270), NF-HEV, NFHEV, Nuclear factor from high endothelial venules

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O95760

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Interleukin-33 (IL33) is a ~30 kDa protein. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.

1. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016

2. Kurowska-Stolarska, M. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 6469-77. PMID: 19841166

3. Komai-Koma, M. et al. (2007) European journal of immunology 37, 2779-86. PMID: 17853410

4. Moussion, C. et al. (2008) PloS one 3, e3331. PMID: 18836528

Note

For research use only

Images

References

Datasheet