Anti-Human SLC7A11 Polyclonal Antibody (HC159014)

Name: Anti-Human SLC7A11 Polyclonal Antibody
Brand: abinScience
SKU: HC159014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HC159014

Description

Anti-Human SLC7A11 Polyclonal Antibody (HC159014) is a rabbit polyclonal antibody detecting SLC7A11. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SLC7A11 (Met1-Arg42).

Target

Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, Cystine/glutamate transporter, SLC7A11, Solute carrier family 7 member 11, xCT

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q9UPY5

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Cystine/glutamate transporter (SLC7A11) is a ~55 kDa protein. Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress. The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. Acts as an inhibitor of ferroptosis by mediating the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Also inhibits ferroptosis by acting as an atypical proton transporter that mediates a slow proton efflux from lysosomes via cystine and glutamate flux.

1. Bridges, CC. et al. (2001) Investigative ophthalmology & visual science 42, 47-54. PMID: 11133847

2. Bassi, MT. et al. (2001) Pflugers Archiv : European journal of physiology 442, 286-96. PMID: 11417227

3. Jiménez-Vidal, M. et al. (2004) The Journal of biological chemistry 279, 11214-21. PMID: 14722095

4. Gasol, E. et al. (2004) The Journal of biological chemistry 279, 31228-36. PMID: 15151999

5. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232

6. Fiore, A. et al. (2022) Molecular cell 82, 920-932.e7. PMID: 35245456

7. Yan, R. et al. (2022) Cell research 32, 687-690. PMID: 35352032

8. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981

Note

For research use only

Images

References

Datasheet

Anti-Human SLC7A11 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SLC7A11 Polyclonal Antibody (HC159014)

Overview

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References

Datasheet

SDS

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