Anti-Feline IL-11 Recombinant Antibody (SAA2802) (FB978013)

Name: Anti-Feline IL-11 Recombinant Antibody (SAA2802)
Brand: abinScience
SKU: FB978013
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	FB978013
Description	Anti-Feline IL-11 Recombinant Antibody (SAA2802) (FB978013) is a feline monoclonal antibody detecting IL-11 in ELISA, Functional assay, Research in vivo. Suitable for Feline. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Multi-Application — Validated across multiple applications.
Species reactivity	Feline
Applications	ELISA, Functional assay, Research in vivo
Host species	Feline
Clonality	Monoclonal
Isotype	IgG1, kappa
Clone ID	SAA2802
Target	IL11, Interleukin 11
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	M3W4F9
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Note	For research use only.

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Datasheet

Anti-Feline IL-11 Recombinant Antibody (SAA2802).pdf

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Anti-Feline IL-11 Recombinant Antibody (SAA2802) (FB978013)

Overview

Images

References

Datasheet

SDS