Anti-Durvalumab Non-Neutralizing Recombinant Antibody (SAA2886) (AV974023)

Name: Anti-Durvalumab Non-Neutralizing Recombinant Antibody (SAA2886)
Brand: abinScience
SKU: AV974023
Price: 168 USD
Availability: InStock

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Overview

Catalog No.	AV974023
Description	Anti-Durvalumab Non-Neutralizing Recombinant Antibody (SAA2886) (AV974023) is a mouse monoclonal antibody detecting Durvalumab in ELISA. Suitable for General. Highlights ●Affinity Purified — Minimal background and high purity for reliable results.
Species reactivity	General
Applications	ELISA
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG1
Clone ID	SAA2886
Expression system	Mammalian cells
Immunogen	Durvalumab
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	CAS: 1428935-60-7
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Programmed cell death 1 ligand 1 (Durvalumab) is a ~33 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. 1. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443 2. Mezzadra, R. et al. (2017) Nature 549, 106-110. PMID: 28813410 3. Burr, ML. et al. (2017) Nature 549, 101-105. PMID: 28813417 4. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419 5. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298 6. Dong, H. et al. (1999) Nature medicine 5, 1365-9. PMID: 10581077 7. Hou, J. et al. (2020) Nature cell biology 22, 1264-1275. PMID: 32929201
Note	For research use only.

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Bioactivity

Detects Durvalumab (Catalog No: HV974026) in indirect ELISA.

References

Datasheet

Anti-Durvalumab Non-Neutralizing Recombinant Antibody (SAA2886).pdf

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Recombinant Proteins

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Anti-Durvalumab Non-Neutralizing Recombinant Antibody (SAA2886) (AV974023)

Overview

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References

Datasheet

SDS