Anti-Daratumumab Neutralizing Recombinant Antibody (SAA2908) (AB691083)

Name: Anti-Daratumumab Neutralizing Recombinant Antibody (SAA2908)
Brand: abinScience
SKU: AB691083
Price: 168 USD
Availability: InStock

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Overview

Catalog No.	AB691083
Description	Anti-Daratumumab Neutralizing Recombinant Antibody (SAA2908) (AB691083) is a mouse monoclonal antibody detecting Daratumumab in ELISA. Suitable for General. Highlights ●Affinity Purified — Minimal background and high purity for reliable results.
Species reactivity	General
Applications	ELISA
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG1
Clone ID	SAA2908
Immunogen	Daratumumab
Endotoxin level	< 10EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	CAS: 945721-28-8
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (Daratumumab) is a ~34 kDa protein. Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. 1. Tohgo, A. et al. (1994) The Journal of biological chemistry 269, 28555-7. PMID: 7961800 2. Takasawa, S. et al. (1993) The Journal of biological chemistry 268, 26052-4. PMID: 8253715 3. Moreschi, I. et al. (2006) Biochemical and biophysical research communications 345, 573-80. PMID: 16690024 4. Deaglio, S. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 395-402. PMID: 9551996 5. Frasca, L. et al. (2006) Blood 107, 2392-9. PMID: 16293598 6. Deaglio, S. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 580-2. PMID: 11259373
Note	For research use only.