

| Catalog No. | AY286243 |
|---|---|
| Description |
Anti-Disitamab Neutralizing Recombinant Antibody (SAA2981) (AY286243) is a mouse monoclonal antibody detecting Disitamab in ELISA. Suitable for General.
Highlights
|
| Species reactivity | General |
| Applications | ELISA |
| Host species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone ID | SAA2981 |
| Expression system | Mammalian cells |
| Immunogen | Disitamab |
| Endotoxin level | < 10 EU/mg as determined by LAL method. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | CAS: 2185868-98-6 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Receptor tyrosine-protein kinase erbB-2 (Disitamab) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. |
| Note | For research use only. |



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