

| Catalog No. | MB840014 | ||||||
|---|---|---|---|---|---|---|---|
| Description |
Anti-Mouse NT-proBNP Polyclonal Antibody (MB840014) is a rabbit polyclonal antibody detecting NT-proBNP in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Species reactivity | Mouse | ||||||
| Applications | ELISA, IHC, WB | ||||||
| Host species | Rabbit | ||||||
| Clonality | Polyclonal | ||||||
| Isotype | IgG | ||||||
| Immunogen | E. coli - derived recombinant Mouse NT-proBNP (Tyr27-Leu121). | ||||||
| Target | 5 kDa cardiac natriuretic peptide, BNP, BNP(77-121), Brain natriuretic factor prohormone, Brain natriuretic peptide, Brain natriuretic peptide 45, Gamma-brain natriuretic peptide, Iso-ANP, Natriuretic peptides B, Nppb, preproBNP, proBNP | ||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||
| Purity | >95% as determined by SDS-PAGE. | ||||||
| Purification | Purified by antigen affinity column. | ||||||
| Accession | P40753 | ||||||
| Form | Liquid | ||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||
| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| Background | Natriuretic peptides B (NPPB/BNP) is a ~14 kDa protein. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3. 1. Koller, KJ. et al. (1991) Science (New York, N.Y.) 252, 120-3. PMID: 1672777 2. Heublein, DM. et al. (2007) Hypertension (Dallas, Tex. : 1979) 49, 1114-9. PMID: 17372040 3. Yoshimura, M. et al. (1991) Circulation 84, 1581-8. PMID: 1914098 4. Jensen, KT. et al. (1998) The American journal of physiology 274, F63-72. PMID: 9458824 5. Liang, F. et al. (2007) Journal of the American College of Cardiology 49, 1071-8. PMID: 17349887 6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034 7. Huntley, BK. et al. (2015) Circulation. Heart failure 8, 89-97. PMID: 25339504 | ||||||
| Note | For research use only. |
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