Anti-Human IL-5 Recombinant Antibody (TEV-53408) (HY218013)

Name: Anti-Human IL-5 Recombinant Antibody (TEV-53408)
Brand: abinScience
SKU: HY218013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY218013

Description

Anti-Human IL-5 Recombinant Antibody (TEV-53408) (HY218013) is a human monoclonal antibody detecting IL-5 in ELISA, Bioactivity: FACS, Functional assay. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, Bioactivity: FACS, Functional assay

Host species

Human

Clonality

Monoclonal

Isotype

IgG4, lambda

Clone ID

TEV-53408

Target

B-cell differentiation factor I, Eosinophil differentiation factor, IL-5, IL5, Interleukin-5, T-cell replacing factor, TRF

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P05113

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-5 (IL5) is a ~15 kDa protein. Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. IL5 is the therapeutic target of mepolizumab (Nucala).

1. Clutterbuck, EJ. et al. (1989) Blood 73, 1504-12. PMID: 2653458

2. Ochiai, K. et al. (1997) Clinical and experimental immunology 107, 198-204. PMID: 9010276

3. Tavernier, J. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 7041-5. PMID: 1495999

4. Kusano, S. et al. (2012) Protein science : a publication of the Protein Society 21, 850-64. PMID: 22528658

5. Alam, R. et al. (1995) International archives of allergy and immunology 107, 226-7. PMID: 7613138

Note

For research use only.

Images

References

Datasheet

Anti-Human IL-5 Recombinant Antibody (TEV-53408).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human IL-5 Recombinant Antibody (TEV-53408) (HY218013)

Overview

Images

References

Datasheet

SDS