| Target |
EC:2.7.10.2, JTK8, LYN, Lck/Yes-related novel protein tyrosine kinase, Tyrosine-protein kinase Lyn, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog, p53Lyn, p56Lyn |
| Background | Tyrosine-protein kinase Lyn is a ~58 kDa protein. Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. 1. de Jesus, AA. et al. (2023) Nature communications 14, 1502. PMID: 369320762. Manié, SN. et al. (1997) The Journal of biological chemistry 272, 4230-6. PMID: 9020138 |
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