| Target |
3D, 3D polymerase, 3Dpol, Capsid protein VP0, Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, Capsid protein VP4, EC:2.7.7.48, EC:3.4.22.28, EC:3.4.22.29, EC:3.6.1.15, Genome polyprotein, P1, P1A, P1B, P1C, P1D, P2, P2A, P2B, P2C, P3, P3A, P3B, P3C, Picornain 2A, Picornain 3C, Protease 2A, Protease 3C, Protein 2A, Protein 2B, Protein 2C, Protein 3A, Protein 3AB, Protein 3B, Protein 3CD, Protein 3D, RNA-directed RNA polymerase, RdRp, VP4-VP2, VPg, Viral protein genome-linked, Virion protein 1, Virion protein 2, Virion protein 3, Virion protein 4 |
| Background | Capsid protein VP1 is a ~81 kDa protein. Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). |
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