Anti-Human Neuregulin-1-beta 1/NRG1-beta 1 Recombinant Antibody (Genentech patent anti-NRG1) (HX096033)

Name: Anti-Human Neuregulin-1-beta 1/NRG1-beta 1 Recombinant Antibody (Genentech patent anti-NRG1)
Brand: abinScience
SKU: HX096033
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HX096033

Description

Anti-Human Neuregulin-1-beta 1/NRG1-beta 1 Recombinant Antibody (Genentech patent anti-NRG1) (HX096033) is a human monoclonal antibody detecting Neuregulin-1/NRG1 in ELISA. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Species reactivity

Human

Applications

ELISA

Host species

Human

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

Genentech patent anti-NRG1

Target

ARIA, Acetylcholine receptor-inducing activity, Breast cancer cell differentiation factor p45, GGF, Glial growth factor, HGL, HRG, HRGA, Heregulin, NDF, NRG1, Neu differentiation factor, Neuregulin-1, Pro-NRG1, Pro-neuregulin-1, membrane-bound isoform, SMDF, Sensory and motor neuron-derived factor

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q02297

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Pro-neuregulin-1, membrane-bound isoform (NRG1) is a ~70 kDa protein. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4.

1. Sweeney, C. et al. (2000) The Journal of biological chemistry 275, 19803-7. PMID: 10867024

2. Plowman, GD. et al. (1993) Nature 366, 473-5. PMID: 7902537

3. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778

Note

For research use only.

Images

References

Datasheet

Anti-Human Neuregulin-1-beta 1/NRG1-beta 1 Recombinant Antibody (Genentech patent anti-NRG1).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human Neuregulin-1-beta 1/NRG1-beta 1 Recombinant Antibody (Genentech patent anti-NRG1) (HX096033)

Overview

Images

References

Datasheet

SDS