Anti-Human Integrin α5β1/ITGA5_ITGB1 Recombinant Antibody (SAA3040) (HY464023)

Name: Anti-Human Integrin α5β1/ITGA5_ITGB1 Recombinant Antibody (SAA3040)
Brand: abinScience
SKU: HY464023
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY464023

Description

Anti-Human Integrin α5β1/ITGA5_ITGB1 Recombinant Antibody (SAA3040) (HY464023) is a human monoclonal antibody detecting Integrin α5β1/ITGA5_ITGB1 in ELISA. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Species reactivity

Human

Applications

ELISA

Host species

Human

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

SAA3040

Target

CD49 antigen-like family member E, CD49e, FNRA, Fibronectin receptor subunit alpha, ITGA5, Integrin alpha-5, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, Integrin alpha-F, VLA-5, CD29, FNRB, Fibronectin receptor subunit beta, GPIIA, Glycoprotein IIa, ITGB1, Integrin beta-1, MDF2, MSK12, VLA-4 subunit beta

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P08648 & P05556

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Integrin alpha-5 (CD49e/ITGA5) is a ~114 kDa protein. Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1.

1. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536

2. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877

3. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887

4. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881

5. Schumacher, S. et al. (2021) Science advances 7. PMID: 33962943

6. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430

7. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 31331973

Note

For research use only.

Images

References

Datasheet

Anti-Human Integrin α5β1/ITGA5_ITGB1 Recombinant Antibody (SAA3040).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human Integrin α5β1/ITGA5_ITGB1 Recombinant Antibody (SAA3040) (HY464023)

Overview

Images

References

Datasheet

SDS