Anti-Human Complement Factor B Reference Antibody (SAR443809, RUO) (HF634036)

Name: Anti-Human Complement Factor B Reference Antibody (SAR443809, RUO)
Brand: abinScience
SKU: HF634036
Price: 370 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HF634036

Description

Anti-Human Complement Factor B Reference Antibody (SAR443809, RUO) (HF634036) is a human monoclonal antibody detecting Complement Factor B.

Species reactivity

Human

Applications

ELISA, FCM, Functional assay

Host species

Human

Clonality

Monoclonal

Isotype

IgG4, kappa

Clone ID

SAR443809

Target

BF, BFD, Ba, Bb, C3/C5 convertase, CFB, Complement factor B, Complement factor B Ba, Complement factor B Bb, EC:3.4.21.47, GBG, Glycine-rich beta glycoprotein, PBF2, Properdin factor B

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P00751

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..

Background

Complement factor B (CFB) is a ~85 kDa protein. Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases. CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases.

1. Pangburn, MK. et al. (1986) The Biochemical journal 235, 723-30. PMID: 3638964

2. Vogt, W. et al. (1978) Immunology 34, 29-40. PMID: 624565

3. DiScipio, RG. et al. (1983) The Journal of biological chemistry 258, 10629-36. PMID: 6554279

4. Vogel, CW. et al. (1982) The Journal of biological chemistry 257, 8292-9. PMID: 6919543

5. Hourcade, DE. et al. (1998) The Journal of biological chemistry 273, 25996-6000. PMID: 9748277

6. Niemann, MA. et al. (1980) Biochemistry 19, 1576-83. PMID: 6769474

Note

For research use only. Not suitable for clinical or therapeutic use.

Images

References

Datasheet

Anti-Human Complement Factor B Reference Antibody (SAR443809, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human Complement Factor B Reference Antibody (SAR443809, RUO) (HF634036)

Overview

Images

References

Datasheet

SDS