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Anti-Human C4B Recombinant Nanobody (SAA3062) (HY567013)

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Overview
Catalog No.HY567013
Species reactivityHuman
ApplicationsELISA, IF
Host speciesAlpaca
IsotypeVHH-His
Clone IDSAA3062
Clonality Monoclonal
Target RecName: Full=Complement C4-B; AltName: Full=Basic complement C4; AltName: Full=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; Contains: RecName: Full=Complement C4 beta chain; Contains: RecName: Full=Complement C4-B alpha chain; Contains: RecName: Full=C4a anaphylatoxin; Contains: RecName: Full=Complement C4b-B; Contains: RecName: Full=C4d-B; Contains: RecName: Full=Complement C4 gamma chain; Flags: Precursor, C4B, Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, /evidence=ECO:0000250|UniProtKB:P0C0L4., Complement C4 beta chain. /id=PRO_0000042699., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]; COG2373, /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., N-linked (GlcNAc...) asparagine. /evidence=ECO:0000269|PubMed:12754519., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., S -> Y (in allotype C4B-long; dbSNP:rs139889867). /evidence=ECO:0000269|PubMed:14574404, ECO:0000269|Ref.2. /id=VAR_023729., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., P -> L (in allotype C4B1-hi). /id=VAR_069160., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., Interchain (with C-820). /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0000269|PubMed:6167582. /id=PRO_0000042700., Complement C4-B alpha chain. /id=PRO_0000042701., C4a anaphylatoxin. /id=PRO_0000042702., Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to...; cd00017, Anaphylatoxin-like. /evidence=ECO:0000255|PROSITE-ProRule:PRU00022., /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0000250|UniProtKB:P0C0L4., R -> S (in Ref. 3; AAR89101). /evidence=ECO:0000305., /evidence=ECO:0000250|UniProtKB:P0C0L4., R -> Q (in Ref. 3; AAR89127). /evidence=ECO:0000305., Cleavage; by C1S, MASP2 and GZMK. /evidence=ECO:0000250|UniProtKB:P0C0L4., Complement C4b-B. /id=PRO_0000042703., Alpha-2-macroglobulin family; pfam00207, Interchain (with C-567). /evidence=ECO:0000250|UniProtKB:P0C0L4., N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255., Interchain (with C-1590). /evidence=ECO:0000250|UniProtKB:P0C0L4., T -> A (in allotype C4B-long and allotype C4B2; dbSNP:rs796750528). /evidence=ECO:0000269|PubMed:14574404, ECO:0000269|Ref.2, ECO:0000269|Ref.3. /id=VAR_023730., Phosphoserine. /evidence=ECO:0000250|UniProtKB:P0C0L4., C4d-B. /id=PRO_0000042704., VT -> LQ (in Ref. 1; AAA99717). /evidence=ECO:0000305., A-macroglobulin TED domain; pfam07678, Isoglutamyl cysteine thioester (Cys-Gln)., Q -> E (in Ref. 8; AA sequence, 9; AA sequence and 10; AA sequence). /evidence=ECO:0000305., G -> D (in allotype C4B2 and allotype C4B5-Rg1; dbSNP:rs2258218). /evidence=ECO:0000269|PubMed:6546707, ECO:0000269|Ref.3. /id=VAR_023731., SQ -> IA (in Ref. 9; AA sequence). /evidence=ECO:0000305., L->P: No effect on hemolytic activity, nor on C1-dependent binding to IgG. /evidence=ECO:0000269|PubMed:2395880., S->C: 30-40% decrease in hemolytic activity and C1-dependent binding to IgG. /evidence=ECO:0000269|PubMed:2395880., I->A: 50-60% decrease in hemolytic activity and C1-dependent binding to IgG. /evidence=ECO:0000269|PubMed:2395880., H->A: 20% decrease in hemolytic activity, 2-fold increase in C1-dependent binding to IgG. /evidence=ECO:0000269|PubMed:2395880., H->D: 2.5-3 fold-decrease in hemolytic activity, 3-fold increase in C1-dependent binding to IgG. /evidence=ECO:0000269|PubMed:2395880., Responsible for effective binding to form amide bonds with immune aggregates or protein antigens. /evidence=ECO:0000269|PubMed:8538770., S -> N (in allotype C4B1a; dbSNP:rs2746414). /evidence=ECO:0000269|PubMed:14989716. /id=VAR_023732., A -> V (in allotype C4B5-Rg1; dbSNP:rs2229403). /evidence=ECO:0000269|PubMed:14989716. /id=VAR_023734., R -> L (in allotype C4B5-Rg1; dbSNP:rs2229409). /evidence=ECO:0000269|PubMed:14989716. /id=VAR_023735., H -> V (in Ref. 9; AA sequence and 13; AA sequence). /evidence=ECO:0000305., R -> V (in Ref. 9; AA sequence and 13; AA sequence). /evidence=ECO:0000305., I -> F (in allotype C4B1-SC01; dbSNP:rs2023616). /evidence=ECO:0000269|PubMed:8575831. /id=VAR_069161., N-linked (GlcNAc...) asparagine. /evidence=ECO:0000269|PubMed:16740002., N-linked (GlcNAc...) asparagine. /evidence=ECO:0000269|PubMed:14760718., Interchain (with C-1566). /evidence=ECO:0000250|UniProtKB:P0C0L4., Sulfotyrosine. /evidence=ECO:0000269|PubMed:3944109., Sulfotyrosine. /evidence=ECO:0000269|PubMed:3944109., Sulfotyrosine. /evidence=ECO:0000269|PubMed:3944109., /id=PRO_0000042705., Complement C4 gamma chain. /id=PRO_0000042706., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0000250|UniProtKB:P0C0L4., A-macroglobulin receptor binding domain; pfam07677, /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., Interchain (with C-1394). /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0007829|PDB:6YSQ., NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical...; cd03584, Interchain (with C-876). /evidence=ECO:0000250|UniProtKB:P0C0L4., NTR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00295., /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., T -> RA (in Ref. 1; AAA99717). /evidence=ECO:0000305., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., H -> Q (in Ref. 1; AAA99717). /evidence=ECO:0000305., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0007829|PDB:6YSQ., /evidence=ECO:0000250|UniProtKB:P0C0L4., /evidence=ECO:0007829|PDB:6YSQ.
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Purified by Nickel column
Accession P0C0L5
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Product Usage Information
Application Dilution
ELISA 1:2000-1:20000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note For research use only
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Anti-Human C4B Recombinant Nanobody (SAA3062)

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