Anti-Human IL-4R alpha Reference Antibody (Elarekibep, RUO) (HB732036)

Name: Anti-Human IL-4R alpha Reference Antibody (Elarekibep, RUO)
Brand: abinScience
SKU: HB732036
Price: 370 USD
Availability: InStock

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Spec:

100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB732036

Description

Anti-Human IL-4R alpha Reference Antibody (Elarekibep, RUO) (HB732036) is a human monoclonal antibody detecting IL-4R alpha.

Species reactivity

Human

Applications

ELISA, FCM, Functional assay

Host species

Human

Clonality

Monoclonal

Isotype

IgG

Clone ID

Elarekibep

Target

CD124, IL-4 receptor subunit alpha, IL-4-binding protein, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, IL4-BP, IL4R, IL4RA, Interleukin-4 receptor subunit alpha, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, Soluble interleukin-4 receptor subunit alpha, sIL4Ralpha/prot

Endotoxin level

< 10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P24394

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

AZD1402, PRS-060

Background

Interleukin-4 receptor subunit alpha (CD124/IL4R) is a ~89 kDa protein. Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. CD124 is the therapeutic target of dupilumab (Dupixent).

1. Andrews, AL. et al. (2006) The Journal of allergy and clinical immunology 118, 858-65. PMID: 17030238

Note

For research use only.

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References

Datasheet