Anti-Human IL-33 Recombinant Antibody (PF-06817024) (HF543023)

Name: Anti-Human IL-33 Recombinant Antibody (PF-06817024)
Brand: abinScience
SKU: HF543023
Price: 191 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HF543023

Description

Anti-Human IL-33 Recombinant Antibody (PF-06817024) (HF543023) is a human monoclonal antibody detecting IL-33 in ELISA, FACS, Functional assay. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, FACS, Functional assay

Host species

Human

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

PF-06817024

Target

C9orf26, IL-1F11, IL-33, IL1F11, IL33, Interleukin-1 family member 11, Interleukin-33, Interleukin-33 (109-270), Interleukin-33 (95-270), Interleukin-33 (99-270), NF-HEV, NFHEV, Nuclear factor from high endothelial venules

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O95760

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-33 (NF-HEV,IL-1F11,C9orf26,IL-33,Interleukin-1 family member 11,IL33,Nuclear factor from high endothelial venules,NFHEV,Interleukin-33,IL1F11) is a ~30 kDa protein. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.

1. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016

2. Kurowska-Stolarska, M. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 6469-77. PMID: 19841166

3. Komai-Koma, M. et al. (2007) European journal of immunology 37, 2779-86. PMID: 17853410

4. Moussion, C. et al. (2008) PloS one 3, e3331. PMID: 18836528

Note

For research use only

Images

References

Datasheet