Anti-HLA-A2-peptide (HMTEVVRHC) Complex & CD3 epsilon Reference Antibody (Graxutamig, RUO) (HY039016)

Name: Anti-HLA-A2-peptide (HMTEVVRHC) Complex & CD3 epsilon Reference Antibody (Graxutamig, RUO)
Brand: abinScience
SKU: HY039016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HY039016
Description	Anti-HLA-A2-peptide (HMTEVVRHC) Complex & CD3 epsilon Reference Antibody (Graxutamig, RUO) (HY039016) is a monoclonal antibody detecting p53.
Species reactivity	Human
Applications	ELISA, FCM, Functional assay
Clonality	Monoclonal
Isotype	SCFV-SCFV-Fc
Clone ID	Graxutamig
Expression system	Mammalian cells
Nature	Recombinant
Target	TP53-target gene 5 protein, TP53-inducible gene 5 protein, TP53TG5, C20orf10, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9Y2B4 & P07766
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate Names	CAS: 3081136-73-1
Background	Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. 1. Guo, A. et al. (2000) Nature cell biology 2, 730-6. PMID: 11025664 2. Bergamaschi, D. et al. (2003) Nature genetics 33, 162-7. PMID: 12524540 3. Louria-Hayon, I. et al. (2003) The Journal of biological chemistry 278, 33134-41. PMID: 12810724 4. An, W. et al. (2004) Cell 117, 735-48. PMID: 15186775 5. Ghosh, A. et al. (2004) Molecular and cellular biology 24, 7987-97. PMID: 15340061 6. Zhao, Y. et al. (2007) The Journal of biological chemistry 282, 11969-81. PMID: 17317671 7. Taira, N. et al. (2007) Molecular cell 25, 725-38. PMID: 17349958 8. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538 9. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990 10. Wu, L. et al. (2011) The Journal of biological chemistry 286, 2236-44. PMID: 20959462
Note	For research use only. Not suitable for clinical or therapeutic use.

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Anti-HLA-A2-peptide (HMTEVVRHC) Complex & CD3 epsilon Reference Antibody (Graxutamig, RUO).pdf

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Anti-HLA-A2-peptide (HMTEVVRHC) Complex & CD3 epsilon Reference Antibody (Graxutamig, RUO) (HY039016)

Overview

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References

Datasheet

SDS