Anti-Human CD35 Reference Antibody (Ledacocept, RUO) (HB625016)

Name: Anti-Human CD35 Reference Antibody (Ledacocept, RUO)
Brand: abinScience
SKU: HB625016
Price: 370 USD
Availability: InStock

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1mg

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Overview

Catalog No.	HB625016
Description	Anti-Human CD35 Reference Antibody (Ledacocept, RUO) (HB625016) is a monoclonal antibody detecting CD35.
Species reactivity	Human
Applications	ELISA, FCM, Functional assay
Clonality	Monoclonal
Isotype	CD35
Expression system	Mammalian cells
Nature	Recombinant
Target	C3BR, C3b/C4b receptor, CD35, CR1, Complement receptor type 1
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P17927
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate Names	CAS: 3083227-23-7
Background	Complement receptor type 1 (CD35/CR1) is a ~223 kDa protein. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. 1. Schifferli, JA. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 140, 899-904. PMID: 2963069 2. Klickstein, LB. et al. (1988) The Journal of experimental medicine 168, 1699-717. PMID: 2972794 3. Krych, M. et al. (1994) The Journal of biological chemistry 269, 13273-8. PMID: 8175757 4. Török, K. et al. (2015) Immunology letters 164, 117-24. PMID: 25742728
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Anti-Human CD35 Reference Antibody (Ledacocept, RUO).pdf

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Anti-Human CD35 Reference Antibody (Ledacocept, RUO) (HB625016)

Overview

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References

Datasheet

SDS