Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Rusubamig, RUO) (JN076036)

Name: Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Rusubamig, RUO)
Brand: abinScience
SKU: JN076036
Price: 370 USD
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Catalog No.	JN076036
Description	Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Rusubamig, RUO) (JN076036) is a human monoclonal antibody detecting PcrV & PsI,PcrV,PsI.
Species reactivity	Pseudomonas aeruginosa
Applications	ELISA, FACS, Functional assay
Host species	Human
Clonality	Monoclonal
Isotype	inmunoglobulina (VH-G1(CH1-5h)-scFvhl-G1(h-CH2-CH3)_L kappa)
Target	PcrV, Virulence-associated V antigen, lcrV, pcrV
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O30527 & Psl
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate Names	CAS: 3077157-52-6
Background	Gremubamab (MEDI3902) is a humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections. • A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of Pseudomonas aeruginosa in Patients with Bronchiectasis., PMID:38754132 • Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates., PMID:30016475 • Pseudomonas aeruginosa Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide., PMID:26333940 • Phase 1 study of MEDI3902, an investigational anti-Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults., PMID:30107283 • AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia., PMID:38678160 • Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature., PMID:28463232 • Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models., PMID:31160288 • Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets., PMID:30185667 • Multifunctional Monoclonal Antibody Targeting Pseudomonas aeruginosa Keratitis in Mice., PMID:33147726 • Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model., PMID:34902264
Note	For research use only.

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Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Rusubamig, RUO).pdf

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Anti-Pseudomonas aeruginosa PcrV & Psl Bispecific Reference Antibody (Rusubamig, RUO) (JN076036)

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