Anti-Human Siglec-10 Reference Antibody (Tasafustobart, RUO) (HV244026)

Name: Anti-Human Siglec-10 Reference Antibody (Tasafustobart, RUO)
Brand: abinScience
SKU: HV244026
Price: 370 USD
Availability: InStock

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Catalog No.	HV244026
Description	Anti-Human Siglec-10 Reference Antibody (Tasafustobart, RUO) (HV244026) is a human monoclonal antibody detecting Siglec-10.
Species reactivity	Human
Applications	ELISA, FCM, Functional assay
Host species	Human
Clonality	Monoclonal
Isotype	IgG4, kappa
Target	SIGLEC10, SLG2, Sialic acid-binding Ig-like lectin 10, Siglec-10, Siglec-like protein 2
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q96LC7
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate Names	CAS: 3082356-05-3
Background	Sialic acid-binding Ig-like lectin 10 (SIGLEC10/SLG2) is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. 1. Munday, J. et al. (2001) The Biochemical journal 355, 489-97. PMID: 11284738 2. Kitzig, F. et al. (2002) Biochemical and biophysical research communications 296, 355-62. PMID: 12163025 3. Zhang, P. et al. (2015) The Journal of surgical research 194, 107-13. PMID: 25450598
Note	For research use only.

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Anti-Human Siglec-10 Reference Antibody (Tasafustobart, RUO).pdf

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Anti-Human Siglec-10 Reference Antibody (Tasafustobart, RUO) (HV244026)

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